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[Go to ROSENOW Bibliography]


"Owing to my becoming of age, these [epilepsy, dementia pr.] and

other studies were unavoidably interrupted." 52R2


  Rosenow in 1952 [52R2] (South Dakota M.J., Sept.) reported that

a pregnant mouse, which reveived repeated intracerebral inoculation

of the streptococcus from epilepsy had remained well,

but one of the 4 offspring died in an apparent gran mal seizure several

weeks after birth (the other three remained well). "This occurrence was first considered as

perhaps an example of hereditary epilepsy. However, a pure culture of the

streptococcus was isolated from the

brain in serial dilution cultures in dextrose-brain broth.  The

streptococcus from the end point of growth produced spasms in 19

and convulsions in 16 of 22 mice that were repeatedly inoculated


  Rosenow [52R2], p. 243, "The recovery from symptoms in nervous

states or psychoses following the removal of infected teeth [from

which neurotropic alpha streptococci were isolated, which on

inoculation in rabbits caused extreme excitation; and the favorable

results from the use of vaccines prepared from neurotropic alpha

streptocci] were taken to indicate that a specific type of

streptococcus might be causative of schizophrenia."

  Rosenow [52R2], p. 245, contrasts reactions of rabbits injected

with material from schizophrenia vs. rabbits injected with material

from epilepsy, with greater hyperirritability in the former and

more convulsions in the latter.  Reactions of mice injected with

material from epilepsy exhibited greater incidence of convulsions

than mice injected with material from well controls.

material directly from nasopharynx, tonsils,

infected teeth or dextrose-brain-broth cultures

             Schizophrenia  Idiopathic-Epilepsy  Well-control

                    RABBITS..............  MICE..................

                       77           106      130      44

Hyperirritability      87%          25%

Convulsions             3%          34%       69%      2%


  Rosenow [52R2] p. 245, "Convincing evidence that specific types

of alpha streptococci may in fact be causative of both epilepsy and

schizophrenia have now been obtained during extensive studies at

Longview Hospital [Cincinnati Ohio].

  p. 248, Rosenow found an increase of specific antibodies and

decrease of corresponding antigen in both schizophrenia following

electroshock therapy and in epilepsy following spontaneous gran mal

seizures, indicating "that preformed so-called sessile antibodies

are mobilized during the course of the violent reactions."  Dr.

Rosenow notes that this raises the possibility that an "inherited

constitution affords the very conditions favorable for alpha

streptococci normally present in the throat and elsewhere of human

beings to acquire specific affinity for structures in the brain..."


  Effects of electroshock:  "The prompt increase of respective

specific streptococcal antibodies and a decrease of corresponding

antigen in schizophrenia following electrically induced convulsion

during electro-shock treatment and in idiopathic epilepsy following

spontaneously occurring grand mal seizures indicate the presence of

specific types of subclinical streptococcal infections and that

preformed, so-called sessile antibodies are mobilized during the

course of the violent reactions."  [52R2, 248 ]


  p. 262, conclusions:

  Streptococci, neurotoxins and schizophrenia:  "the consistent

isolation of alpha streptococci in studies of idiopathic epilepsy

and schizophrenia, the reproduction in important respects of the

disease pictures in animals, the proof of their serologic

specificity by the special methods employed, and the data obtained

in these studies indicate: (1) that persons suffering from epilepsy

and from schizophrenia harbor in nasopharynx, in pulpless teeth,

and sometimes in their blood, specific types of alpha streptococci

of low general but high and specific 'neurotropic' virulence; (2)

that the streptococci produce neurotoxins which have predilection

for certain structures in the brain and thus may play a role in

pathogenesis and (3) that attempts to combat such inapparent

infections specifically by passive and active immunization with the

respective antigens and antibodies are indicated in addition to

present-day methods of prevention and cure."[52R2]

  We are reminded of JC Hurley's recent work [Lancet, 1993 May 1,

341(8853):1133-5] indicating endotoxins encountered in sepsis may

merely comprise markers for transition to wall-deficient bacterial

a smaller phase, thus it is tempting to speculate that this may

also be so in the case of presumed "neurotoxins".

[Go to ROSENOW Bibliography]