55R2-325


AGGLUTINATIVE TITER BY SEASON
Agglutinative titer of serum of persons on admission, chiefly schizophrenics, for streptococci isolated in
 studies of schizophrenia was least pronounced in autumn (34, 31),slightly higher in summer (43, 49),
 and highest in winter (57, 54) and spring (60, 50)



AGGLUTINATIVE TITER OF SPINAL FLUID & BLOOD SERUM FOR ORGANISM FROM SCHIZOPHRENIA
					Agglutinative titer of blood serum:
			Agglutinative titer of spinal fluid
Schizophrenia					49	33	 50	43
Psychophysiologic autonomic
 and visceral disease 				48	36 	 43	46
Mental disorders generally considered 
as due to circulatory disturbances 		55	34	 43	42
Mental deficiency				54	38	 56	53
Intoxication alcohol				47	32
Intoxication alcohol or drugs					 50	43
Other obscure mental disorders			55	46
Psychoneurotic disorders 					 49	44
Chronic brain syndromes due to syphilis				 21	20
Chronic brain disorders of unknown cause			 42	43
Well, non-contacts						 14	13




CHLORPROMAZINE CONTRAINDICATED AS SCHIZOPHRENIA THERAPY [55R2-330]


"The agglutinative titer for the streptococcus [of schizophrenia]


of the blood serum of schizophrenics receiving chlorpromazine


unfortunately has been found far lower and of the urine


significantly greater than in comparable schizophrenics not


receiving chlorpromazine.  ... The administration of chlorpromazine


and serpasil in the treatment of schizophrenics was found to cause


a reduction instead of a hoped for increase in the agglutinative


titer of the serum of schizophrenics for the streptococcus isolated


in studies of schizophrenia.  ... from the immunological standpoint


[the use of chlorpromazine to treat schizophrenia] is


contraindicated, for it does not eliminate the basic cause, the


specific neurotropic streptococcus, nor does it neutralize the


specific toxicogenic streptococcal antigen."55R2






STREPTOCOCCUS IN NASOPHARYNX, SOMETIMES BLOOD IN SCHIZO. [55R2-328]


These and previous studies indicate that "... schizophrenia and


related mental disorders ... are due to a specific type of non


hemolytic neurotropic streptococcal infection or intoxication. ...


The streptococcus of schizophrenia has a low, general virulence but


is highly neurotropic in tht it localizes electively in the brain


of persons stricken and in animals on intravenous injection.  In


keeping with this low general virulence, the general health is


maintained, and stimulation of the formation of antibody is


minimal; hence the disease process tends to continue unabated. ...


It is realized how contrary to current psychiatric tenets the


concept that schizophrenia and related mental disorders can


possibly be due to an infectious process, but the results of


bacteriologic studies by the special methods used indicate that



such is nevertheless the case."55R2






INJECTION OF ANTIBODY AND ANTIGEN FOR CUTANEOUS TESTS  [55R2]


  The tests for circulating antigen or antibody were made by


injecting approx. .03 ml of respective antibody or antigen


solutions intradermally into the skin of the volar aspect of the


forearm. [55R2]






VACCINE PREPARATION SUMMARY  55R2


  Streptococcal thermal antibody solutions and vaccines were


prepared routinely from the streptococci in the dense glycerol


saturated NaCl solution suspensions.  The vaccine represented


suspensions in NaCl solution of 2 billion streptococci per ml. and


heated at 70 degrees C for one hour.  ... [55R2]